InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC30A5

Summary

InnateDB Gene

IDBG-25156.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC30A5

Gene Name

solute carrier family 30 (zinc transporter), member 5

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000145740

Encoded Proteins

IDBP-25160

solute carrier family 30 (zinc transporter), member 5

IDBP-237169

solute carrier family 30 (zinc transporter), member 5

IDBP-473827

solute carrier family 30 (zinc transporter), member 5

IDBP-481627

solute carrier family 30 (zinc transporter), member 5

IDBP-479038

solute carrier family 30 (zinc transporter), member 5

IDBP-481052

solute carrier family 30 (zinc transporter), member 5

IDBP-811376

solute carrier family 30 (zinc transporter), member 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:69093646-69131069

Strand

Forward strand

Band

q13.1

Transcripts

ENST00000380860	ENSP00000370241
ENST00000396591	ENSP00000379836
ENST00000504103	ENSP00000426751
ENST00000502979	ENSP00000421251
ENST00000507354
ENST00000513937	ENSP00000427111
ENST00000512367
ENST00000511158	ENSP00000423078
ENST00000621204	ENSP00000483105

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005385	zinc ion transmembrane transporter activity
GO:0008270	zinc ion binding
GO:0008324	cation transmembrane transporter activity

Biological Process

GO:0006812	cation transport
GO:0006824	cobalt ion transport
GO:0006829	zinc ion transport
GO:0006882	cellular zinc ion homeostasis
GO:0010043	response to zinc ion
GO:0010155	regulation of proton transport
GO:0044267	cellular protein metabolic process
GO:0055085	transmembrane transport
GO:0071577	zinc ion transmembrane transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005794	Golgi apparatus
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030141	secretory granule
GO:0030667	secretory granule membrane