InnateDB Protein
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IDBP-237201.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ARHGAP5
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Protein Name
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Rho GTPase activating protein 5
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Synonyms
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GFI2; p190-B; p190BRhoGAP; RhoGAP5;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000379827
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InnateDB Gene
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IDBG-4437 (ARHGAP5)
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Protein Structure
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Function |
GTPase-activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of RASA1/p120GAP.
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Subcellular Localization |
Cytoplasm. Membrane; Peripheral membrane protein. Note=Also membrane-associated when found in fibrillar patterns that colocalize with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin.
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Disease Associations |
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Tissue Specificity |
Expressed in kidney, brain, liver and lung.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
21
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000198
Rho GTPase-activating protein domain
IPR008936
Rho GTPase activation protein
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PFAM |
PF00620
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PRINTS |
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PIRSF |
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SMART |
SM00324
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TIGRFAMs |
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Modification |
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SwissProt |
Q13017
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PhosphoSite |
PhosphoSite-Q13017
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
394
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UniGene |
Hs.607635
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RefSeq |
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HUGO |
HGNC:675
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OMIM |
602680
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CCDS |
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HPRD |
04060
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IMGT |
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EMBL |
AB209751
AK292966
BC032723
BC050059
BC075799
BC129928
BC129929
CH471078
U17032
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GenPept |
AAA95963
AAH32723
AAH50059
AAH75799
AAI29929
AAI29930
BAD92988
BAF85655
EAW65935
EAW65936
EAW65937
EAW65938
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