InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARHGAP5

Summary

InnateDB Gene

IDBG-4437.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP5

Gene Name

Rho GTPase activating protein 5

Synonyms

GFI2; p190-B; p190BRhoGAP; RhoGAP5

Species

Homo sapiens

Ensembl Gene

ENSG00000100852

Encoded Proteins

IDBP-4439

Rho GTPase activating protein 5

IDBP-237201

Rho GTPase activating protein 5

IDBP-365395

Rho GTPase activating protein 5

IDBP-365400

Rho GTPase activating protein 5

IDBP-603033

Rho GTPase activating protein 5

IDBP-591976

Rho GTPase activating protein 5

IDBP-598717

Rho GTPase activating protein 5

IDBP-591380

Rho GTPase activating protein 5

IDBP-585956

Rho GTPase activating protein 5

IDBP-599768

Rho GTPase activating protein 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:32076114-32159728

Strand

Forward strand

Band

q12

Transcripts

ENST00000345122	ENSP00000371897
ENST00000216743
ENST00000396582	ENSP00000379827
ENST00000432921	ENSP00000393307
ENST00000433497	ENSP00000407395
ENST00000555814	ENSP00000452372
ENST00000556611	ENSP00000452222
ENST00000539826	ENSP00000441692
ENST00000556191	ENSP00000451579
ENST00000554090	ENSP00000451061
ENST00000557643	ENSP00000452606

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0042169	SH2 domain binding

Biological Process

GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0006184	GTP catabolic process
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0008361	regulation of cell size
GO:0030335	positive regulation of cell migration
GO:0030879	mammary gland development
GO:0032321	positive regulation of Rho GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000035133

View Gene Order

ENSBTAG00000027024

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

REACT_11051

Rho GTPase cycle pathway

REACT_11044

Signaling by Rho GTPases pathway

REACT_111102

Signal Transduction pathway

KEGG

hsa04670

Leukocyte transendothelial migration pathway

hsa04510

Focal adhesion pathway

INOH

PID NCI

rhoa_reg_pathway

Regulation of RhoA activity

rac1_pathway

RAC1 signaling pathway

Cross-References

SwissProt

Q13017

TrEMBL

G3V360 G3V444 G3V5I7

UniProt Splice Variant

Entrez Gene

394

UniGene

Hs.592313 Hs.607635

RefSeq

NM_001173 NM_001030055 XM_005267635 XM_005267636

HUGO

HGNC:675

OMIM

602680

CCDS

CCDS45095 CCDS32062

HPRD

04060

IMGT

EMBL

AB209751 AK292966 AL161665 BC032723 BC050059 BC075799 BC129928 BC129929 CH471078 U17032

GenPept

AAA95963 AAH32723 AAH50059 AAH75799 AAI29929 AAI29930 BAD92988 BAF85655 EAW65935 EAW65936 EAW65937 EAW65938

RNA Seq Atlas

394