InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DKK3

Summary

InnateDB Protein

IDBP-237364.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DKK3

Protein Name

dickkopf homolog 3 (Xenopus laevis)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000379762

InnateDB Gene

IDBG-32224 (DKK3)

Protein Structure

UniProt Annotation

Function

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highest expression in heart, brain, and spinal cord. {ECO:0000269PubMed:10570958, ECO:0000269Ref.4}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0007275	multicellular organismal development
GO:0009653	anatomical structure morphogenesis
GO:0016055	Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030325	adrenal gland development
GO:0032348	negative regulation of aldosterone biosynthetic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000065	negative regulation of cortisol biosynthetic process