InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP21

Summary

InnateDB Protein

IDBP-237511.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP21

Protein Name

Rho GTPase activating protein 21

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000379709

InnateDB Gene

IDBG-63069 (ARHGAP21)

Protein Structure

UniProt Annotation

Function

Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. {ECO:0000269PubMed:15793564, ECO:0000269PubMed:16184169}.

Subcellular Localization

Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent on interaction with GTP-bound ARF1.

Disease Associations

Tissue Specificity

Widely expressed with higher expression in brain, heart, skeletal muscle and placenta. {ECO:0000269PubMed:12056806}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0007030	Golgi organization
GO:0007165	signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0051683	establishment of Golgi localization
GO:0051684	maintenance of Golgi location
GO:0072384	organelle transport along microtubule

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005794	Golgi apparatus
GO:0005856	cytoskeleton
GO:0030054	cell junction
GO:0030659	cytoplasmic vesicle membrane