Version 5.4
Homo sapiens Gene: ARHGAP21
Summary
InnateDB Gene IDBG-63069.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGAP21
Gene Name Rho GTPase activating protein 21
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000107863
Encoded Proteins
IDBP-63071
Rho GTPase activating protein 21
IDBP-63073
Rho GTPase activating protein 21
IDBP-237511
Rho GTPase activating protein 21
IDBP-369848
Rho GTPase activating protein 21
IDBP-369850
Rho GTPase activating protein 21
IDBP-369856
Rho GTPase activating protein 21
IDBP-369858
Rho GTPase activating protein 21
IDBP-807393
Rho GTPase activating protein 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:24583609-24723668
Strand Reverse strand
Band p12.1
Transcripts
ENST00000320481 ENSP00000365604
ENST00000376410 ENSP00000365592
ENST00000396432 ENSP00000379709
ENST00000418033 ENSP00000389940
ENST00000418325 ENSP00000402761
ENST00000446003 ENSP00000405018
ENST00000416305 ENSP00000400566
ENST00000486374
ENST00000477190
ENST00000482792
ENST00000493154
ENST00000476067
ENST00000483114
ENST00000476499
ENST00000472150
ENST00000463892
ENST00000612832 ENSP00000480005
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0007030 Golgi organization
GO:0007165 signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0051683 establishment of Golgi localization
GO:0051684 maintenance of Golgi location
GO:0072384 organelle transport along microtubule
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005794 Golgi apparatus
GO:0005856 cytoskeleton
GO:0030054 cell junction
GO:0030659 cytoplasmic vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036591
View Gene Order
ENSBTAG00000021857
Not yet available
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q5T5U3
TrEMBL E7ESW5
UniProt Splice Variant
Entrez Gene 57584
UniGene Hs.459909 Hs.524195 Hs.618951 Hs.720921 Hs.721916 Hs.722402
RefSeq NM_020824 XM_005252542 XM_005252543 XM_005252546 XM_005252547 XM_006717487 XM_006717488 XM_006717489
HUGO HGNC:23725
OMIM 609870
CCDS CCDS7144
HPRD 06445
IMGT
EMBL AB037845 AF480466 AL355979 AL392104 AL834495 BC022931 BX537570
GenPept AAH22931 AAM22955 BAA92662 CAD39153 CAD97787 CAI14323 CAI40176
RNA Seq Atlas 57584

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca