InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PKIA

Summary

InnateDB Protein

IDBP-237561.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PKIA

Protein Name

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

Synonyms

PRKACN1;

Species

Homo sapiens

Ensembl Protein

ENSP00000379696

InnateDB Gene

IDBG-26102 (PKIA)

Protein Structure

UniProt Annotation

Function

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004862	cAMP-dependent protein kinase inhibitor activity
GO:0005515	protein binding
GO:0034236	protein kinase A catalytic subunit binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006469	negative regulation of protein kinase activity
GO:0010389	regulation of G2/M transition of mitotic cell cycle
GO:0042308	negative regulation of protein import into nucleus
GO:0043086	negative regulation of catalytic activity
GO:2000480	negative regulation of cAMP-dependent protein kinase activity