InnateDB Protein
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IDBP-237606.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TSEN34
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Protein Name
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tRNA splicing endonuclease 34 homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000379671
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InnateDB Gene
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IDBG-68287 (TSEN34)
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Protein Structure
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Function |
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'- end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269PubMed:15109492}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:15109492}. Nucleus, nucleolus {ECO:0000269PubMed:15109492}. Note=May be transiently localized in the nucleolus.
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Disease Associations |
Pontocerebellar hypoplasia 2C (PCH2C) [MIM:612390]: A disorder characterized by an abnormally small cerebellum and brainstem, and progressive microcephaly from birth combined with extrapyramidal dyskinesia. Severe chorea occurs and epilepsy is frequent. There are no signs of spinal cord anterior horn cells degeneration. {ECO:0000269PubMed:18711368}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
18
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0000379
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tRNA-type intron splice site recognition and cleavage
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GO:0006388
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tRNA splicing, via endonucleolytic cleavage and ligation
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GO:0006397
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mRNA processing
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GO:0090502
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RNA phosphodiester bond hydrolysis, endonucleolytic
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Cellular Component |
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PDB ID |
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InterPro |
IPR006676
tRNA-splicing endonuclease
IPR006677
tRNA intron endonuclease, catalytic domain-like
IPR016690
tRNA-splicing endonuclease, SEN34 subunit
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PFAM |
PF01974
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PRINTS |
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PIRSF |
PIRSF017250
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BSV6
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PhosphoSite |
PhosphoSite-Q9BSV6
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TrEMBL |
B0V3J0
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UniProt Splice Variant |
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Entrez Gene |
79042
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UniGene |
Hs.15580
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RefSeq |
NP_001070914
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HUGO |
HGNC:15506
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OMIM |
608754
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CCDS |
CCDS42609
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HPRD |
10038
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IMGT |
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EMBL |
AC012314
AK025929
BC004530
BC020805
CH471135
CU151838
CU457734
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GenPept |
AAH04530
AAH20805
BAB15284
CAP19124
CAQ09596
EAW72203
EAW72205
EAW72207
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