InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DVL2

Summary

InnateDB Protein

IDBP-23765.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DVL2

Protein Name

dishevelled, dsh homolog 2 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000005340

InnateDB Gene

IDBG-23761 (DVL2)

Protein Structure

UniProt Annotation

Function

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 125 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	125 [view]
Protein-Protein	123 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0042802	identical protein binding
GO:0043621	protein self-association

Biological Process

GO:0001843	neural tube closure
GO:0001934	positive regulation of protein phosphorylation
GO:0003007	heart morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0006366	transcription from RNA polymerase II promoter
GO:0007379	segment specification
GO:0007507	heart development
GO:0016055	Wnt signaling pathway
GO:0021535	cell migration in hindbrain
GO:0022007	convergent extension involved in neural plate elongation
GO:0034613	cellular protein localization
GO:0035282	segmentation
GO:0035329	hippo signaling
GO:0035556	intracellular signal transduction
GO:0035567	non-canonical Wnt signaling pathway
GO:0043507	positive regulation of JUN kinase activity
GO:0044340	canonical Wnt signaling pathway involved in regulation of cell proliferation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060026	convergent extension
GO:0060029	convergent extension involved in organogenesis
GO:0060070	canonical Wnt signaling pathway
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0090103	cochlea morphogenesis
GO:0090179	planar cell polarity pathway involved in neural tube closure
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0030136	clathrin-coated vesicle
GO:0031410	cytoplasmic vesicle
GO:0045177	apical part of cell
GO:0045334	clathrin-coated endocytic vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR000591 DEP domain
IPR001158 DIX domain
IPR001478 PDZ domain
IPR003351 Dishevelled protein domain
IPR008339 Dishevelled family
IPR008341 Dishevelled-2
IPR024580 Dishevelled C-terminal

PFAM

PF00610
PF00778
PF00595
PF13180
PF02377
PF12316

PRINTS

PR01760
PR01762

PIRSF

SMART

SM00049
SM00021
SM00228

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt