InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SOX6

Summary

InnateDB Protein

IDBP-237658.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOX6

Protein Name

SRY (sex determining region Y)-box 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000379644

InnateDB Gene

IDBG-33494 (SOX6)

Protein Structure

UniProt Annotation

Function

Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00267, ECO:0000269PubMed:16442531}.

Disease Associations

Tissue Specificity

Expressed in a wide variety of tissues, most abundantly in skeletal muscle. {ECO:0000269PubMed:11255018}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000902	cell morphogenesis
GO:0001701	in utero embryonic development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007517	muscle organ development
GO:0009791	post-embryonic development
GO:0010468	regulation of gene expression
GO:0016458	gene silencing
GO:0021778	oligodendrocyte cell fate specification
GO:0030097	hemopoiesis
GO:0030218	erythrocyte differentiation
GO:0032332	positive regulation of chondrocyte differentiation
GO:0042692	muscle cell differentiation
GO:0045165	cell fate commitment
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048708	astrocyte differentiation
GO:0048709	oligodendrocyte differentiation
GO:0048821	erythrocyte development
GO:0051216	cartilage development
GO:0055007	cardiac muscle cell differentiation
GO:0061036	positive regulation of cartilage development
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:2000741	positive regulation of mesenchymal stem cell differentiation