Version 5.4
Homo sapiens Gene: SOX6
Summary
InnateDB Gene IDBG-33494.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOX6
Gene Name SRY (sex determining region Y)-box 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000110693
Encoded Proteins
IDBP-33500
SRY (sex determining region Y)-box 6
IDBP-237658
SRY (sex determining region Y)-box 6
IDBP-592918
SRY (sex determining region Y)-box 6
IDBP-601650
SRY (sex determining region Y)-box 6
IDBP-597354
SRY (sex determining region Y)-box 6
IDBP-600172
SRY (sex determining region Y)-box 6
IDBP-593856
SRY (sex determining region Y)-box 6
IDBP-586799
SRY (sex determining region Y)-box 6
IDBP-585394
SRY (sex determining region Y)-box 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:15966449-16739591
Strand Reverse strand
Band p15.2
Transcripts
ENST00000352083
ENST00000316399 ENSP00000324948
ENST00000396356 ENSP00000379644
ENST00000528252 ENSP00000432134
ENST00000527619 ENSP00000434455
ENST00000528429 ENSP00000433233
ENST00000527840
ENST00000524650
ENST00000531297
ENST00000533411 ENSP00000436170
ENST00000530378 ENSP00000432577
ENST00000533870
ENST00000533658
ENST00000526673 ENSP00000434892
ENST00000529469 ENSP00000432596
ENST00000525835
ENST00000524520
ENST00000525259
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000902 cell morphogenesis
GO:0001701 in utero embryonic development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007517 muscle organ development
GO:0009791 post-embryonic development
GO:0010468 regulation of gene expression
GO:0016458 gene silencing
GO:0021778 oligodendrocyte cell fate specification
GO:0030097 hemopoiesis
GO:0030218 erythrocyte differentiation
GO:0032332 positive regulation of chondrocyte differentiation
GO:0042692 muscle cell differentiation
GO:0045165 cell fate commitment
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048708 astrocyte differentiation
GO:0048709 oligodendrocyte differentiation
GO:0048821 erythrocyte development
GO:0051216 cartilage development
GO:0055007 cardiac muscle cell differentiation
GO:0061036 positive regulation of cartilage development
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:2000741 positive regulation of mesenchymal stem cell differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051910
View Gene Order
ENSBTAG00000044185
Not yet available
Cross-References
SwissProt
TrEMBL E9PN02 E9PQ67 E9PQ78
UniProt Splice Variant
Entrez Gene 55553
UniGene Hs.596281 Hs.601154 Hs.629542 Hs.712586 Hs.739277
RefSeq NM_001145811 NM_001145819 NM_017508 NM_033326
HUGO HGNC:16421
OMIM 607257
CCDS CCDS53604 CCDS53605 CCDS7821
HPRD 06267
IMGT
EMBL AC009869 AC013595 AC026639 AC027016 AC068405 AC100865 AC103794
GenPept
RNA Seq Atlas 55553

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca