InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HOXA10

Summary

InnateDB Protein

IDBP-237715.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOXA10

Protein Name

homeobox A10

Synonyms

HOX1; HOX1.8; HOX1H; PL;

Species

Homo sapiens

Ensembl Protein

ENSP00000379633

InnateDB Gene

IDBG-404968 (HOXA10)

Protein Structure

UniProt Annotation

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	12 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0030528	transcription regulator activity
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter