InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNB5

Summary

InnateDB Protein

IDBP-237717.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNB5

Protein Name

guanine nucleotide binding protein (G protein), beta 5

Synonyms

GB5;

Species

Homo sapiens

Ensembl Protein

ENSP00000379626

InnateDB Gene

IDBG-12415 (GNB5)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in multiple tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	45 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0031682	G-protein gamma-subunit binding
GO:0051087	chaperone binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007603	phototransduction, visible light
GO:0016056	rhodopsin mediated signaling pathway
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:1901386	negative regulation of voltage-gated calcium channel activity

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR001632 G-protein, beta subunit
IPR001680 WD40 repeat
IPR016346 Guanine nucleotide-binding protein, beta subunit
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat

PFAM

PF00400

PRINTS

PR00319
PR00320

PIRSF

PIRSF002394

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References