InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GNB5

Summary

InnateDB Gene

IDBG-12415.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNB5

Gene Name

guanine nucleotide binding protein (G protein), beta 5

Synonyms

GB5

Species

Homo sapiens

Ensembl Gene

ENSG00000069966

Encoded Proteins

IDBP-12417

guanine nucleotide binding protein (G protein), beta 5

IDBP-12419

guanine nucleotide binding protein (G protein), beta 5

IDBP-237717

guanine nucleotide binding protein (G protein), beta 5

IDBP-603922

guanine nucleotide binding protein (G protein), beta 5

IDBP-603921

guanine nucleotide binding protein (G protein), beta 5

IDBP-603381

guanine nucleotide binding protein (G protein), beta 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:52115105-52191369

Strand

Reverse strand

Band

q21.2

Transcripts

ENST00000261837	ENSP00000261837
ENST00000358784	ENSP00000351635
ENST00000396335	ENSP00000379626
ENST00000557936
ENST00000559348
ENST00000560085
ENST00000558519	ENSP00000453339
ENST00000559541
ENST00000561313	ENSP00000454185
ENST00000558122
ENST00000560075
ENST00000560116	ENSP00000453176

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	45 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0031682	G-protein gamma-subunit binding
GO:0051087	chaperone binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007603	phototransduction, visible light
GO:0016056	rhodopsin mediated signaling pathway
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:1901386	negative regulation of voltage-gated calcium channel activity

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032192

View Gene Order

ENSBTAG00000003762

Not yet available

Pathways

NETPATH

REACTOME

REACT_23946

Prostacyclin signalling through prostacyclin receptor pathway

REACT_23876

Platelet homeostasis pathway

REACT_20653

ADP signalling through P2Y purinoceptor 12 pathway

REACT_19140

ADP signalling through P2Y purinoceptor 1 pathway

REACT_20647

Thromboxane signalling through TP receptor pathway

REACT_21384

Thrombin signalling through proteinase activated receptors (PARs) pathway

REACT_24023

Vasopressin regulates renal water homeostasis via Aquaporins pathway

REACT_18283

G alpha (q) signalling events pathway

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_19231

G alpha (i) signalling events pathway

REACT_19290

G beta:gamma signalling through PI3Kgamma pathway

REACT_19145

G beta:gamma signalling through PLC beta pathway

REACT_18407

G alpha (12/13) signalling events pathway

REACT_19327

G alpha (s) signalling events pathway

REACT_19333

G alpha (z) signalling events pathway

REACT_18377

Glucagon-type ligand receptors pathway

REACT_18372

Class B/2 (Secretin family receptors) pathway

REACT_15457

G-protein activation pathway

REACT_15295

Opioid Signalling pathway

REACT_21254

Presynaptic function of Kainate receptors pathway

REACT_18274

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway

REACT_18339

Adrenaline,noradrenaline inhibits insulin secretion pathway

REACT_18325

Regulation of insulin secretion pathway

REACT_1505

Integration of energy metabolism pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_172761

Ca2+ pathway pathway

REACT_172694

beta-catenin independent WNT signaling pathway

REACT_11045

Signaling by Wnt pathway

REACT_13685

Neuronal System pathway

REACT_14797

Signaling by GPCR pathway

REACT_798

Platelet activation, signaling and aggregation pathway

REACT_19388

G-protein beta:gamma signalling pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21312

Activation of Kainate Receptors upon glutamate binding pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_21340

GPCR ligand binding pathway

REACT_15370

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

REACT_111217

Metabolism pathway

REACT_20524

Signal amplification pathway

REACT_23887

Aquaporin-mediated transport pathway

REACT_604

Hemostasis pathway

KEGG

hsa04062

Chemokine signaling pathway pathway

INOH

INOH website

GPCR Adenosine A2A receptor signaling pathway pathway

INOH website

GPCR GroupI metabotropic glutamate receptor signaling pathway pathway

INOH website

GPCR Dopamine D1like receptor signaling pathway pathway

INOH website

GPCR signaling pathway

PID NCI

txa2pathway

Thromboxane A2 receptor signaling

cone_pathway

Visual signal transduction: Cones

rhodopsin_pathway

Visual signal transduction: Rods

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.155090 Hs.708730 Hs.734358 Hs.739331

RefSeq

NM_006578 NM_016194

HUGO

OMIM

CCDS

CCDS10149 CCDS45261

HPRD

09191

IMGT

EMBL

GenPept

RNA Seq Atlas