InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LILRB1

Summary

InnateDB Protein

IDBP-237727.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LILRB1

Protein Name

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1

Synonyms

CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7; MIR7;

Species

Homo sapiens

Ensembl Protein

ENSP00000379622

InnateDB Gene

IDBG-68880 (LILRB1)

Protein Structure

UniProt Annotation

Function

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. {ECO:0000269PubMed:11907092, ECO:0000269PubMed:9285411, ECO:0000269PubMed:9842885}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed predominantly on B-cells and monocytes, and at lower levels on dendritic cells. Detected on a low percentage of T-cells and natural killer (NK) cells. {ECO:0000269PubMed:9285411, ECO:0000269PubMed:9842885}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008157	protein phosphatase 1 binding
GO:0030107	HLA-A specific inhibitory MHC class I receptor activity
GO:0030109	HLA-B specific inhibitory MHC class I receptor activity
GO:0032393	MHC class I receptor activity
GO:0042169	SH2 domain binding
GO:0042288	MHC class I protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001915	negative regulation of T cell mediated cytotoxicity
GO:0002230	positive regulation of defense response to virus by host
GO:0002309	T cell proliferation involved in immune response
GO:0002740	negative regulation of cytokine secretion involved in immune response
GO:0002767	immune response-inhibiting cell surface receptor signaling pathway
GO:0002774	Fc receptor mediated inhibitory signaling pathway
GO:0007165	signal transduction
GO:0009615	response to virus
GO:0010628	positive regulation of gene expression
GO:0014063	negative regulation of serotonin secretion
GO:0031623	receptor internalization
GO:0032609	interferon-gamma production
GO:0032689	negative regulation of interferon-gamma production
GO:0032945	negative regulation of mononuclear cell proliferation
GO:0035548	negative regulation of interferon-beta secretion
GO:0042130	negative regulation of T cell proliferation
GO:0042536	negative regulation of tumor necrosis factor biosynthetic process
GO:0043065	positive regulation of apoptotic process
GO:0045077	negative regulation of interferon-gamma biosynthetic process
GO:0045786	negative regulation of cell cycle
GO:0045806	negative regulation of endocytosis
GO:0045919	positive regulation of cytolysis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045953	negative regulation of natural killer cell mediated cytotoxicity
GO:0046636	negative regulation of alpha-beta T cell activation
GO:0050776	regulation of immune response
GO:0051607	defense response to virus
GO:0051926	negative regulation of calcium ion transport
GO:0071222	cellular response to lipopolysaccharide
GO:0072643	interferon-gamma secretion
GO:0097028	dendritic cell differentiation
GO:2000669	negative regulation of dendritic cell apoptotic process
GO:2001180	negative regulation of interleukin-10 secretion
GO:2001183	negative regulation of interleukin-12 secretion
GO:2001186	negative regulation of CD8-positive, alpha-beta T cell activation
GO:2001189	negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:2001193	positive regulation of gamma-delta T cell activation involved in immune response
GO:2001199	negative regulation of dendritic cell differentiation
GO:2001202	negative regulation of transforming growth factor-beta secretion
GO:2001205	negative regulation of osteoclast development