InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAX1BP1

Summary

InnateDB Protein

IDBP-237752.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAX1BP1

Protein Name

Tax1 (human T-cell leukemia virus type I) binding protein 1

Synonyms

CALCOCO3; T6BP; TXBP151;

Species

Homo sapiens

Ensembl Protein

ENSP00000379612

InnateDB Gene

IDBG-10692 (TAX1BP1)

Protein Structure

UniProt Annotation

Function

Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. {ECO:0000269PubMed:10435631, ECO:0000269PubMed:10920205}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in all tissues tested.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	37 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019900	kinase binding

Biological Process

GO:0006915	apoptotic process
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032480	negative regulation of type I interferon production
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)