InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TSPO

Summary

InnateDB Protein

IDBP-237863.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TSPO

Protein Name

translocator protein (18kDa)

Synonyms

BPBS; BZRP; DBI; IBP; MBR; mDRC; PBR; PBS; pk18; PKBS; PTBR;

Species

Homo sapiens

Ensembl Protein

ENSP00000379563

InnateDB Gene

IDBG-10470 (TSPO)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005497	androgen binding
GO:0005515	protein binding
GO:0008503	benzodiazepine receptor activity
GO:0015485	cholesterol binding

Biological Process

GO:0006626	protein targeting to mitochondrion
GO:0006694	steroid biosynthetic process
GO:0006783	heme biosynthetic process
GO:0006811	ion transport
GO:0006820	anion transport
GO:0006821	chloride transport
GO:0006915	apoptotic process
GO:0007268	synaptic transmission
GO:0007568	aging
GO:0008202	steroid metabolic process
GO:0008283	cell proliferation
GO:0008347	glial cell migration
GO:0010042	response to manganese ion
GO:0010266	response to vitamin B1
GO:0010940	positive regulation of necrotic cell death
GO:0014012	peripheral nervous system axon regeneration
GO:0030325	adrenal gland development
GO:0032374	regulation of cholesterol transport
GO:0032570	response to progesterone
GO:0032720	negative regulation of tumor necrosis factor production
GO:0033574	response to testosterone
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0048265	response to pain
GO:0048266	behavioral response to pain
GO:0048678	response to axon injury
GO:0050810	regulation of steroid biosynthetic process
GO:0051901	positive regulation of mitochondrial depolarization
GO:0051928	positive regulation of calcium ion transport
GO:0060242	contact inhibition
GO:0060252	positive regulation of glial cell proliferation
GO:0060253	negative regulation of glial cell proliferation
GO:0071222	cellular response to lipopolysaccharide
GO:0071294	cellular response to zinc ion
GO:0071476	cellular hypotonic response
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome