InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FBXO22

Summary

InnateDB Protein

IDBP-23790.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXO22

Protein Name

F-box protein 22

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000307833

InnateDB Gene

IDBG-23786 (FBXO22)

Protein Structure

UniProt Annotation

Function

Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. {ECO:0000269PubMed:22972877}.

Subcellular Localization

Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in liver, also enriched in cardiac muscle. {ECO:0000269PubMed:22972877}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006464	cellular protein modification process
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006913	nucleocytoplasmic transport
GO:0009267	cellular response to starvation
GO:0010830	regulation of myotube differentiation
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0048742	regulation of skeletal muscle fiber development
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process