Version 5.4
Homo sapiens Gene: FBXO22
Summary
InnateDB Gene IDBG-23786.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO22
Gene Name F-box protein 22
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167196
Encoded Proteins
IDBP-23790
F-box protein 22
IDBP-378182
F-box protein 22
IDBP-745541
IDBP-745252
IDBP-747498
IDBP-747512
IDBP-746809
IDBP-746098
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:75903859-75942510
Strand Forward strand
Band q24.2
Transcripts
ENST00000308275 ENSP00000307833
ENST00000453211 ENSP00000396442
ENST00000561885 ENSP00000458022
ENST00000565036 ENSP00000457177
ENST00000564220 ENSP00000457297
ENST00000569749 ENSP00000456198
ENST00000569022 ENSP00000457531
ENST00000565131
ENST00000569054 ENSP00000457569
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006464 cellular protein modification process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006913 nucleocytoplasmic transport
GO:0009267 cellular response to starvation
GO:0010830 regulation of myotube differentiation
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0048742 regulation of skeletal muscle fiber development
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030018 Z disc
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032309
View Gene Order
ENSBTAG00000002833
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.458959 Hs.591115 Hs.601357
RefSeq NM_012170 NM_147188
HUGO
OMIM
CCDS CCDS10287 CCDS45310
HPRD 16437
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca