InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDE1C

Summary

InnateDB Protein

IDBP-238017.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE1C

Protein Name

phosphodiesterase 1C, calmodulin-dependent 70kDa

Synonyms

cam-PDE 1C; hCam-3; Hcam3;

Species

Homo sapiens

Ensembl Protein

ENSP00000379494

InnateDB Gene

IDBG-11559 (PDE1C)

Protein Structure

UniProt Annotation

Function

Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in several tissues, including brain and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0005516	calmodulin binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0008152	metabolic process
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR013706 3\'5\'-cyclic nucleotide phosphodiesterase N-terminal
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF00233
PF08499

PRINTS

PR00387

PIRSF

SMART

SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt