Version 5.4
Homo sapiens Gene: PDE1C
Summary
InnateDB Gene IDBG-11559.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE1C
Gene Name phosphodiesterase 1C, calmodulin-dependent 70kDa
Synonyms cam-PDE 1C; hCam-3; Hcam3
Species Homo sapiens
Ensembl Gene ENSG00000154678
Encoded Proteins
IDBP-11561
phosphodiesterase 1C, calmodulin-dependent 70kDa
IDBP-238015
phosphodiesterase 1C, calmodulin-dependent 70kDa
IDBP-238017
phosphodiesterase 1C, calmodulin-dependent 70kDa
IDBP-238019
phosphodiesterase 1C, calmodulin-dependent 70kDa
IDBP-238023
phosphodiesterase 1C, calmodulin-dependent 70kDa
IDBP-238025
phosphodiesterase 1C, calmodulin-dependent 70kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1C, are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 [PubMed 1326532]).[supplied by OMIM, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:31751179-32299329
Strand Reverse strand
Band p14.3
Transcripts
ENST00000321453 ENSP00000318105
ENST00000396193 ENSP00000379496
ENST00000396191 ENSP00000379494
ENST00000396189 ENSP00000379492
ENST00000396184 ENSP00000379487
ENST00000396182 ENSP00000379485
ENST00000479980
ENST00000478736
ENST00000482681
ENST00000464881
ENST00000495221
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0005516 calmodulin binding
GO:0046872 metal ion binding
Biological Process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007608 sensory perception of smell
GO:0008152 metabolic process
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0005929 cilium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004347
View Gene Order
ENSBTAG00000002739
Not yet available
Pathways
NETPATH
REACTOME
REACT_15408
Cam-PDE 1 activation pathway
REACT_9000
Calmodulin induced events pathway
REACT_9053
CaM pathway pathway
REACT_111064
DAG and IP3 signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12079
PLC-gamma1 signalling pathway
REACT_12478
EGFR interacts with phospholipase C-gamma pathway
REACT_9417
Signaling by EGFR pathway
REACT_15426
PLC beta mediated events pathway
REACT_15295
Opioid Signalling pathway
REACT_115720
PLCG1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21310
Phospholipase C-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_111102
Signal Transduction pathway
REACT_15526
G-protein mediated events pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_15307
Ca-dependent events pathway
REACT_116125
Disease pathway
KEGG
hsa04740
Olfactory transduction pathway
hsa00230
Purine metabolism pathway
hsa04020
Calcium signaling pathway pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL F8W905 Q75MW3
UniProt Splice Variant
Entrez Gene 5137
UniGene Hs.143821 Hs.290550 Hs.545069 Hs.595197 Hs.728862
RefSeq NM_001191056 NM_001191057 NM_001191058 NM_001191059 NM_005020 XM_005249769
HUGO HGNC:8776
OMIM 602987
CCDS CCDS5437 CCDS55099 CCDS55100
HPRD 04287
IMGT
EMBL AC004931 AC005589 AC006377 AC007033 AC007093 AC018637
GenPept AAC29142
RNA Seq Atlas 5137

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca