InnateDB Protein
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IDBP-238234.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UPK3A
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Protein Name
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uroplakin 3A
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Synonyms
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UP3A; UPIII; UPIIIA; UPK3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000379391
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InnateDB Gene
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IDBG-11393 (UPK3A)
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Protein Structure
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Function |
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER). {ECO:0000250}.
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Disease Associations |
Note=Mutations in UPK3A have been detected in patients with renal adyplasia suggesting a possible involvement of this gene in kidney and urinary tract anomalies.
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Tissue Specificity |
Expressed in ureter. {ECO:0000269PubMed:9846985}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O75631
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PhosphoSite |
PhosphoSite-O75631
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
7380
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UniGene |
Hs.632787
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RefSeq |
NP_001161046
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HUGO |
HGNC:12580
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OMIM |
611559
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CCDS |
CCDS54539
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HPRD |
15625
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IMGT |
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EMBL |
AB010116
AB010637
AF085808
AL008718
BC069544
BC108900
CR456608
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GenPept |
AAC34888
AAH69544
AAI08901
BAA25678
BAA31460
CAG30494
CAI17948
CAQ08673
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