InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GTF2A2

Summary

InnateDB Protein

IDBP-238284.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GTF2A2

Protein Name

general transcription factor IIA, 2, 12kDa

Synonyms

HsT18745; TF2A2; TFIIA;

Species

Homo sapiens

Ensembl Protein

ENSP00000379373

InnateDB Gene

IDBG-14626 (GTF2A2)

Protein Structure

UniProt Annotation

Function

TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. {ECO:0000269PubMed:11030333}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0017025	TBP-class protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051123	RNA polymerase II transcriptional preinitiation complex assembly

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005672	transcription factor TFIIA complex
GO:0030054	cell junction

Protein Structure and Domains

PDB ID

InterPro

IPR003194 Transcription initiation factor IIA, gamma subunit
IPR009083 Transcription factor IIA, helical
IPR009088 Transcription factor IIA, beta-barrel
IPR015871 Transcription initiation factor IIA, gamma subunit, C-terminal
IPR015872 Transcription initiation factor IIA, gamma subunit, N-terminal

PFAM

PF02751
PF02268

PRINTS

PIRSF

PIRSF009415

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P52657