InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ELMO1

Summary

InnateDB Protein

IDBP-238292.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ELMO1

Protein Name

engulfment and cell motility 1

Synonyms

CED-12; CED12; ELMO-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000379360

InnateDB Gene

IDBG-12649 (ELMO1)

Protein Structure

UniProt Annotation

Function

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. {ECO:0000269PubMed:11595183, ECO:0000269PubMed:12134158}.

Subcellular Localization

Cytoplasm. Cell membrane. Note=Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.

Disease Associations

Tissue Specificity

Widely expressed, with a higher expression in the spleen and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017124	SH3 domain binding

Biological Process

GO:0006911	phagocytosis, engulfment
GO:0006915	apoptotic process
GO:0006928	cellular component movement
GO:0016032	viral process
GO:0016601	Rac protein signal transduction
GO:0030036	actin cytoskeleton organization
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response
GO:0050690	regulation of defense response to virus by virus