InnateDB Protein
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IDBP-238296.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ELMO1
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Protein Name
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engulfment and cell motility 1
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Synonyms
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CED-12; CED12; ELMO-1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000379355
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InnateDB Gene
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IDBG-12649 (ELMO1)
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Protein Structure
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Function |
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. {ECO:0000269PubMed:11595183, ECO:0000269PubMed:12134158}.
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Subcellular Localization |
Cytoplasm. Cell membrane. Note=Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.
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Disease Associations |
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Tissue Specificity |
Widely expressed, with a higher expression in the spleen and placenta.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q92556
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PhosphoSite |
PhosphoSite-Q92556
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9844
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UniGene |
Hs.739086
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RefSeq |
NP_001034548
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HUGO |
HGNC:16286
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OMIM |
606420
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CCDS |
CCDS5450
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HPRD |
12102
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IMGT |
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EMBL |
AF398885
AK126565
AL136787
BC003051
BC064635
BC077074
BC114341
CH236951
CH471073
D87457
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GenPept |
AAH03051
AAH64635
AAH77074
AAI14342
AAL14466
BAA13397
BAC86597
CAB66721
EAL23979
EAW94076
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