InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NRP1

Summary

InnateDB Protein

IDBP-238352.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRP1

Protein Name

neuropilin 1

Synonyms

BDCA4; CD304; NP1; NRP; VEGF165R;

Species

Homo sapiens

Ensembl Protein

ENSP00000379317

InnateDB Gene

IDBG-68532 (NRP1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005021	vascular endothelial growth factor-activated receptor activity
GO:0017154	semaphorin receptor activity
GO:0019838	growth factor binding
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0009887	organ morphogenesis
GO:0035767	endothelial cell chemotaxis
GO:0038084	vascular endothelial growth factor signaling pathway
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0071526	semaphorin-plexin signaling pathway

Cellular Component

GO:0016020

membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000421 Coagulation factor 5/8 C-terminal type domain
IPR000859 CUB domain
IPR000998 MAM domain
IPR008979 Galactose-binding domain-like
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR014648 Neuropilin
IPR022579 Neuropilin-1, C-terminal

PFAM

PF00754
PF00431
PF00629
PF11980

PRINTS

PR00020

PIRSF

PIRSF036960

SMART

SM00231
SM00042
SM00137

TIGRFAMs

Post-translational Modifications

Modification

Cross-References