InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NRP1

Summary

InnateDB Gene

IDBG-68532.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRP1

Gene Name

neuropilin 1

Synonyms

BDCA4; CD304; NP1; NRP; VEGF165R

Species

Homo sapiens

Ensembl Gene

ENSG00000099250

Encoded Proteins

IDBP-68534

neuropilin 1

IDBP-68536

neuropilin 1

IDBP-68538

neuropilin 1

IDBP-68544

neuropilin 1

IDBP-68546

neuropilin 1

IDBP-68548

neuropilin 1

IDBP-68552

neuropilin 1

IDBP-238352

neuropilin 1

IDBP-372554

neuropilin 1

IDBP-372581

neuropilin 1

IDBP-372584

neuropilin 1

IDBP-372593

neuropilin 1

IDBP-372598

neuropilin 1

IDBP-811886

neuropilin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:33177492-33336262

Strand

Reverse strand

Band

p11.22

Transcripts

ENST00000265371	ENSP00000265371
ENST00000374875	ENSP00000364009
ENST00000374867	ENSP00000364001
ENST00000374823	ENSP00000363956
ENST00000374822	ENSP00000363955
ENST00000374821	ENSP00000363954
ENST00000374816	ENSP00000363949
ENST00000395995	ENSP00000379317
ENST00000413802	ENSP00000390447
ENST00000418675	ENSP00000416147
ENST00000431894	ENSP00000393071
ENST00000432372	ENSP00000408911
ENST00000455749	ENSP00000390567
ENST00000466932	ENSP00000476896

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005021	vascular endothelial growth factor-activated receptor activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0015026	coreceptor activity
GO:0017154	semaphorin receptor activity
GO:0019838	growth factor binding
GO:0019955	cytokine binding
GO:0038085	vascular endothelial growth factor binding
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0001569	patterning of blood vessels
GO:0001764	neuron migration
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002040	sprouting angiogenesis
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007411	axon guidance
GO:0007413	axonal fasciculation
GO:0007507	heart development
GO:0008045	motor neuron axon guidance
GO:0009611	response to wounding
GO:0009887	organ morphogenesis
GO:0010595	positive regulation of endothelial cell migration
GO:0014911	positive regulation of smooth muscle cell migration
GO:0016358	dendrite development
GO:0016477	cell migration
GO:0021612	facial nerve structural organization
GO:0021636	trigeminal nerve morphogenesis
GO:0021637	trigeminal nerve structural organization
GO:0021675	nerve development
GO:0021785	branchiomotor neuron axon guidance
GO:0021828	gonadotrophin-releasing hormone neuronal migration to the hypothalamus
GO:0030517	negative regulation of axon extension
GO:0031290	retinal ganglion cell axon guidance
GO:0035729	cellular response to hepatocyte growth factor stimulus
GO:0035767	endothelial cell chemotaxis
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0038084	vascular endothelial growth factor signaling pathway
GO:0038190	VEGF-activated neuropilin signaling pathway
GO:0043524	negative regulation of neuron apoptotic process
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048012	hepatocyte growth factor receptor signaling pathway
GO:0048485	sympathetic nervous system development
GO:0048666	neuron development
GO:0048841	regulation of axon extension involved in axon guidance
GO:0048842	positive regulation of axon extension involved in axon guidance
GO:0048843	negative regulation of axon extension involved in axon guidance
GO:0048844	artery morphogenesis
GO:0048846	axon extension involved in axon guidance
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918	positive chemotaxis
GO:0060301	positive regulation of cytokine activity
GO:0060385	axonogenesis involved in innervation
GO:0060627	regulation of vesicle-mediated transport
GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching
GO:0060978	angiogenesis involved in coronary vascular morphogenesis
GO:0060982	coronary artery morphogenesis
GO:0061299	retina vasculature morphogenesis in camera-type eye
GO:0061441	renal artery morphogenesis
GO:0061549	sympathetic ganglion development
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071526	semaphorin-plexin signaling pathway
GO:0071679	commissural neuron axon guidance
GO:0090259	regulation of retinal ganglion cell axon guidance
GO:0097102	endothelial tip cell fate specification
GO:0097490	sympathetic neuron projection extension
GO:0097491	sympathetic neuron projection guidance
GO:1901166	neural crest cell migration involved in autonomic nervous system development
GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance
GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance
GO:1902336	positive regulation of retinal ganglion cell axon guidance
GO:1902378	VEGF-activated neuropilin signaling pathway involved in axon guidance
GO:1902946	protein localization to early endosome
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0002116	semaphorin receptor complex
GO:0005615	extracellular space
GO:0005769	early endosome
GO:0005829	cytosol
GO:0005883	neurofilament
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030426	growth cone
GO:0031410	cytoplasmic vesicle
GO:0043025	neuronal cell body
GO:0043235	receptor complex
GO:0097443	sorting endosome