InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPFFR2

Summary

InnateDB Protein

IDBP-238408.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPFFR2

Protein Name

neuropeptide FF receptor 2

Synonyms

GPR74; HLWAR77; NPFF2; NPGPR;

Species

Homo sapiens

Ensembl Protein

ENSP00000379321

InnateDB Gene

IDBG-23097 (NPFFR2)

Protein Structure

UniProt Annotation

Function

Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Isoform 1 is abundant in placenta. Relatively highly expressed in thymus, testis, and small intestine. Expressed at low levels in several tissues including spleen, prostate, brain, heart, ovary, colon, kidney, lung, liver and pancreas and not expressed in skeletal muscle and leukocytes. Isoform 2 expression is highest in placenta (but at relatively low level compared to isoform 1). Very low level of expression in numerous tissues including adipose tissue and many brain regions. Isoform 3 is expressed in brain and heart and, at lower levels, in kidney, liver, lung and pancreas. {ECO:0000269PubMed:10079187}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0008188	neuropeptide receptor activity
GO:0031628	opioid receptor binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0009582	detection of abiotic stimulus
GO:0043408	regulation of MAPK cascade
GO:0045761	regulation of adenylate cyclase activity
GO:2000479	regulation of cAMP-dependent protein kinase activity

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0015629	actin cytoskeleton
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR005395 Neuropeptide FF receptor family
IPR005397 Neuropeptide FF receptor, type 2
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01012
PR01570
PR01572

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y5X5