Homo sapiens Protein: AURKA | |||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||
InnateDB Protein | IDBP-238567.6 | ||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||
Gene Symbol | AURKA | ||||||||||||||||||||||||||||||
Protein Name | aurora kinase A | ||||||||||||||||||||||||||||||
Synonyms | AIK; ARK1; AURA; AURORA2; BTAK; PPP1R47; STK15; STK6; STK7; | ||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||
Ensembl Protein | ENSP00000379250 | ||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-81805 (AURKA) | ||||||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||||||
Function | Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis. {ECO:0000269PubMed:11039908, ECO:0000269PubMed:11551964, ECO:0000269PubMed:12390251, ECO:0000269PubMed:13678582, ECO:0000269PubMed:14523000, ECO:0000269PubMed:14702041, ECO:0000269PubMed:14990569, ECO:0000269PubMed:15128871, ECO:0000269PubMed:15147269, ECO:0000269PubMed:15987997, ECO:0000269PubMed:17125279, ECO:0000269PubMed:17360485, ECO:0000269PubMed:17604723, ECO:0000269PubMed:18056443, ECO:0000269PubMed:18615013, ECO:0000269PubMed:19351716, ECO:0000269PubMed:19357306, ECO:0000269PubMed:19668197, ECO:0000269PubMed:19812038, ECO:0000269PubMed:20643351, ECO:0000269PubMed:9606188}. | ||||||||||||||||||||||||||||||
Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase. Colocalized with SIRT2 at centrosome. Moves to the midbody during both telophase and cytokinesis. Associates with both the pericentriolar material (PCM) and centrioles. {ECO:0000250}. | ||||||||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||||||||
Tissue Specificity | Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. | ||||||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 244 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00069
PF07714 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||||||||||||||
SMART |
SM00220
SM00219 |
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TIGRFAMs | |||||||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||||
SwissProt | O14965 | ||||||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-O14965 | ||||||||||||||||||||||||||||||
TrEMBL | Q5QPD4 | ||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||
Entrez Gene | 6790 | ||||||||||||||||||||||||||||||
UniGene | Hs.608070 | ||||||||||||||||||||||||||||||
RefSeq | NP_940836 | ||||||||||||||||||||||||||||||
HUGO | HGNC:11393 | ||||||||||||||||||||||||||||||
OMIM | 603072 | ||||||||||||||||||||||||||||||
CCDS | CCDS13451 | ||||||||||||||||||||||||||||||
HPRD | 04352 | ||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||
EMBL | AF008551 AF011467 AF011468 AF195942 AF195943 AF195944 AF195945 AF195946 AF195947 AL121914 BC001280 BC002499 BC006423 BC027464 CH471077 D84212 | ||||||||||||||||||||||||||||||
GenPept | AAC12708 AAC23448 AAC63902 AAF29508 AAH01280 AAH02499 AAH06423 AAH27464 BAA23592 CAC12717 EAW75550 EAW75551 EAW75552 EAW75553 EAW75554 EAW75555 EAW75556 EAW75557 EAW75558 EAW75559 EAW75561 EAW75562 | ||||||||||||||||||||||||||||||