InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AURKA

Summary

InnateDB Protein

IDBP-238569.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AURKA

Protein Name

aurora kinase A

Synonyms

AIK; ARK1; AURA; AURORA2; BTAK; PPP1R47; STK15; STK6; STK7;

Species

Homo sapiens

Ensembl Protein

ENSP00000379249

InnateDB Gene

IDBG-81805 (AURKA)

Protein Structure

UniProt Annotation

Function

Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis. {ECO:0000269PubMed:11039908, ECO:0000269PubMed:11551964, ECO:0000269PubMed:12390251, ECO:0000269PubMed:13678582, ECO:0000269PubMed:14523000, ECO:0000269PubMed:14702041, ECO:0000269PubMed:14990569, ECO:0000269PubMed:15128871, ECO:0000269PubMed:15147269, ECO:0000269PubMed:15987997, ECO:0000269PubMed:17125279, ECO:0000269PubMed:17360485, ECO:0000269PubMed:17604723, ECO:0000269PubMed:18056443, ECO:0000269PubMed:18615013, ECO:0000269PubMed:19351716, ECO:0000269PubMed:19357306, ECO:0000269PubMed:19668197, ECO:0000269PubMed:19812038, ECO:0000269PubMed:20643351, ECO:0000269PubMed:9606188}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase. Colocalized with SIRT2 at centrosome. Moves to the midbody during both telophase and cytokinesis. Associates with both the pericentriolar material (PCM) and centrioles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 244 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	244 [view]
Protein-Protein	239 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0007051	spindle organization
GO:0007067	mitotic nuclear division
GO:0030030	cell projection organization
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031647	regulation of protein stability
GO:0032091	negative regulation of protein binding
GO:0043146	spindle stabilization
GO:0045840	positive regulation of mitosis
GO:0046605	regulation of centrosome cycle
GO:0046777	protein autophosphorylation
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

GO:0005634	nucleus
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005876	spindle microtubule
GO:0015630	microtubule cytoskeleton
GO:0030496	midbody
GO:0031616	spindle pole centrosome
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt