Homo sapiens Protein: NCOA1 | |||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||||||
InnateDB Protein | IDBP-238703.7 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | NCOA1 | ||||||||||||||||||||||||||
Protein Name | nuclear receptor coactivator 1 | ||||||||||||||||||||||||||
Synonyms | bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160; SRC1; | ||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||
Ensembl Protein | ENSP00000379197 | ||||||||||||||||||||||||||
InnateDB Gene | IDBG-33884 (NCOA1) | ||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||
Function | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269PubMed:10449719, ECO:0000269PubMed:12954634, ECO:0000269PubMed:7481822, ECO:0000269PubMed:9223281, ECO:0000269PubMed:9223431, ECO:0000269PubMed:9296499, ECO:0000269PubMed:9427757}. | ||||||||||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}. | ||||||||||||||||||||||||||
Disease Associations | Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children. | ||||||||||||||||||||||||||
Tissue Specificity | Widely expressed. {ECO:0000269PubMed:15313887, ECO:0000269PubMed:9427757}. | ||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 169 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
|
||||||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||
InterPro |
IPR000014
PAS domain IPR009110 Nuclear receptor coactivator, interlocking IPR010011 Domain of unknown function DUF1518 IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain IPR013767 PAS fold IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking IPR014935 Steroid receptor coactivator IPR017426 Nuclear receptor coactivator |
||||||||||||||||||||||||||
PFAM |
PF13188
PF13426 PF07469 PF00010 PF00989 PF08815 PF08832 |
||||||||||||||||||||||||||
PRINTS | |||||||||||||||||||||||||||
PIRSF |
PIRSF038181
|
||||||||||||||||||||||||||
SMART |
SM00091
SM00353 |
||||||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||
SwissProt | Q15788 | ||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q15788 | ||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 8648 | ||||||||||||||||||||||||||
UniGene | Hs.733185 | ||||||||||||||||||||||||||
RefSeq | NP_671766 | ||||||||||||||||||||||||||
HUGO | HGNC:7668 | ||||||||||||||||||||||||||
OMIM | 602691 | ||||||||||||||||||||||||||
CCDS | CCDS42660 | ||||||||||||||||||||||||||
HPRD | 04070 | ||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | AC013459 AC093798 AJ000881 AJ000882 AY633656 BC111533 BC111534 CH471053 EF660499 U19179 U40396 U59302 U90661 | ||||||||||||||||||||||||||
GenPept | AAA64187 AAB50242 AAC50305 AAC50631 AAI11534 AAI11535 AAT47737 AAX93184 ABS29266 CAA04371 CAA04372 EAX00746 | ||||||||||||||||||||||||||