InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BMP7

Summary

InnateDB Protein

IDBP-238707.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BMP7

Protein Name

bone morphogenetic protein 7

Synonyms

OP-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000379204

InnateDB Gene

IDBG-82028 (BMP7)

Protein Structure

UniProt Annotation

Function

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in the kidney and bladder. Lower levels seen in the brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	28 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding

Biological Process

GO:0001501	skeletal system development
GO:0001503	ossification
GO:0001654	eye development
GO:0001656	metanephros development
GO:0001657	ureteric bud development
GO:0001707	mesoderm formation
GO:0001822	kidney development
GO:0001823	mesonephros development
GO:0001837	epithelial to mesenchymal transition
GO:0007389	pattern specification process
GO:0007411	axon guidance
GO:0007435	salivary gland morphogenesis
GO:0008285	negative regulation of cell proliferation
GO:0009880	embryonic pattern specification
GO:0009887	organ morphogenesis
GO:0010664	negative regulation of striated muscle cell apoptotic process
GO:0010800	positive regulation of peptidyl-threonine phosphorylation
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010942	positive regulation of cell death
GO:0016358	dendrite development
GO:0030198	extracellular matrix organization
GO:0030326	embryonic limb morphogenesis
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0030855	epithelial cell differentiation
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032355	response to estradiol
GO:0033280	response to vitamin D
GO:0034116	positive regulation of heterotypic cell-cell adhesion
GO:0034504	protein localization to nucleus
GO:0035239	tube morphogenesis
GO:0040007	growth
GO:0042325	regulation of phosphorylation
GO:0042326	negative regulation of phosphorylation
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043065	positive regulation of apoptotic process
GO:0043401	steroid hormone mediated signaling pathway
GO:0043407	negative regulation of MAP kinase activity
GO:0043434	response to peptide hormone
GO:0045597	positive regulation of cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045746	negative regulation of Notch signaling pathway
GO:0045786	negative regulation of cell cycle
GO:0045839	negative regulation of mitosis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048468	cell development
GO:0048593	camera-type eye morphogenesis
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048762	mesenchymal cell differentiation
GO:0048812	neuron projection morphogenesis
GO:0050768	negative regulation of neurogenesis
GO:0051216	cartilage development
GO:0060272	embryonic skeletal joint morphogenesis
GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395	SMAD protein signal transduction
GO:0060445	branching involved in salivary gland morphogenesis
GO:0060485	mesenchyme development
GO:0060548	negative regulation of cell death
GO:0060686	negative regulation of prostatic bud formation
GO:0060687	regulation of branching involved in prostate gland morphogenesis
GO:0070487	monocyte aggregation
GO:0071456	cellular response to hypoxia
GO:0072040	negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
GO:0072125	negative regulation of glomerular mesangial cell proliferation
GO:0072133	metanephric mesenchyme morphogenesis
GO:0072134	nephrogenic mesenchyme morphogenesis
GO:0072136	metanephric mesenchymal cell proliferation involved in metanephros development
GO:1900006	positive regulation of dendrite development
GO:1900106	positive regulation of hyaluranon cable assembly
GO:2000121	regulation of removal of superoxide radicals