InnateDB Protein
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IDBP-23876.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RASSF6
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Protein Name
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Ras association (RalGDS/AF-6) domain family member 6
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000303877
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InnateDB Gene
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IDBG-23874 (RASSF6)
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Protein Structure
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Function |
Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity). {ECO:0000250}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart. {ECO:0000269PubMed:17404571}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000159
Ras-association
IPR011524
SARAH domain
IPR029071
Ubiquitin-related domain
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PFAM |
PF00788
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PRINTS |
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PIRSF |
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SMART |
SM00314
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TIGRFAMs |
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Modification |
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SwissProt |
Q6ZTQ3
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PhosphoSite |
PhosphoSite-Q6ZTQ3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
166824
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UniGene |
Hs.603193
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RefSeq |
NP_803876
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HUGO |
HGNC:20796
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OMIM |
612620
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CCDS |
CCDS3559
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HPRD |
15220
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IMGT |
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EMBL |
AK126346
AY217664
AY217665
BC058835
CR749283
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GenPept |
AAH58835
AAO61689
AAO61690
BAC86530
CAH18138
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