Version 5.4
Homo sapiens Protein: RASSF6
Summary
InnateDB Protein IDBP-23880.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RASSF6
Protein Name Ras association (RalGDS/AF-6) domain family member 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000335582
InnateDB Gene IDBG-23874 (RASSF6)
Protein Structure
UniProt Annotation
Function Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart. {ECO:0000269PubMed:17404571}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000159 Ras-association
IPR011524 SARAH domain
IPR029071 Ubiquitin-related domain
PFAM PF00788
PRINTS
PIRSF
SMART SM00314
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZTQ3
PhosphoSite PhosphoSite-Q6ZTQ3
TrEMBL
UniProt Splice Variant
Entrez Gene 166824
UniGene Hs.603193
RefSeq NP_001257321
HUGO HGNC:20796
OMIM 612620
CCDS CCDS58905
HPRD 15220
IMGT
EMBL AK126346 AY217664 AY217665 BC058835 CR749283
GenPept AAH58835 AAO61689 AAO61690 BAC86530 CAH18138

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca