InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AFP

Summary

InnateDB Protein

IDBP-238818.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AFP

Protein Name

alpha-fetoprotein

Synonyms

AFPD; FETA; HPAFP;

Species

Homo sapiens

Ensembl Protein

ENSP00000379138

InnateDB Gene

IDBG-23783 (AFP)

Protein Structure

UniProt Annotation

Function

Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Plasma. Synthesized by the fetal liver and yolk sac.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046872	metal ion binding

Biological Process

GO:0001542	ovulation from ovarian follicle
GO:0006810	transport
GO:0019953	sexual reproduction
GO:0042448	progesterone metabolic process
GO:0060395	SMAD protein signal transduction

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000264 ALB/AFP/VDB
IPR001703 Alpha-fetoprotein
IPR014760 Serum albumin, N-terminal
IPR020858 Serum albumin-like
IPR021177 Serum albumin/Alpha-fetoprotein

PFAM

PF00273

PRINTS

PR00802
PR00803

PIRSF

PIRSF002520

SMART

SM00103

TIGRFAMs

Post-translational Modifications

Modification

Cross-References