InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MARCH8

Summary

InnateDB Protein

IDBP-238879.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MARCH8

Protein Name

membrane-associated ring finger (C3HC4) 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000379116

InnateDB Gene

IDBG-71943 (MARCH8)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS. {ECO:0000269PubMed:12582153, ECO:0000269PubMed:14722266, ECO:0000269PubMed:18389477, ECO:0000269PubMed:19117940, ECO:0000269PubMed:19566897}.

Subcellular Localization

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Broadly expressed. Present in immature dendritic cells (at protein level). {ECO:0000269PubMed:12582153, ECO:0000269PubMed:14722266}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0000209

protein polyubiquitination

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0016021	integral component of membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0031901	early endosome membrane