Version 5.4
Homo sapiens Gene: MARCH8
Summary
InnateDB Gene IDBG-71943.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARCH8
Gene Name membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165406
Encoded Proteins
IDBP-71947
membrane-associated ring finger (C3HC4) 8
IDBP-238879
membrane-associated ring finger (C3HC4) 8
IDBP-373989
membrane-associated ring finger (C3HC4) 8
IDBP-373999
membrane-associated ring finger (C3HC4) 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:45454585-45594906
Strand Reverse strand
Band q11.22
Transcripts
ENST00000319836 ENSP00000317087
ENST00000395769 ENSP00000379116
ENST00000453424 ENSP00000411848
ENST00000453980 ENSP00000396678
ENST00000476962
ENST00000602712
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0042289 MHC class II protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0002495 antigen processing and presentation of peptide antigen via MHC class II
GO:0016567 protein ubiquitination
GO:0045347 negative regulation of MHC class II biosynthetic process
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031901 early endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025702
View Gene Order
ENSBTAG00000019537
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.499489
RefSeq NM_001002266 NM_001282866 NM_145021 XM_005271804 XM_006717704 XM_006717705
HUGO
OMIM
CCDS CCDS60519 CCDS7213
HPRD 17466
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca