InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CARS

Summary

InnateDB Protein

IDBP-23888.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CARS

Protein Name

cysteinyl-tRNA synthetase

Synonyms

CARS1; CYSRS; MGC:11246;

Species

Homo sapiens

Ensembl Protein

ENSP00000278224

InnateDB Gene

IDBG-23884 (CARS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm.

Disease Associations

Note=A chromosomal aberration involving CARS is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with ALK.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0000166	nucleotide binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004817	cysteine-tRNA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0006423	cysteinyl-tRNA aminoacylation
GO:0010467	gene expression

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
IPR015413 Methionyl/Leucyl tRNA synthetase
IPR015803 Cysteine-tRNA ligase
IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase

PFAM

PF09334
PF01406

PRINTS

PR00983

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P49589