InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNASE3

Summary

InnateDB Protein

IDBP-2389.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNASE3

Protein Name

ribonuclease, RNase A family, 3

Synonyms

ECP; RNS3;

Species

Homo sapiens

Ensembl Protein

ENSP00000302324

InnateDB Gene

IDBG-2387 (RNASE3)

Protein Structure

UniProt Annotation

Function

Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. {ECO:0000269PubMed:19450231, ECO:0000269PubMed:2501794}.

Subcellular Localization

Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004540	ribonuclease activity
GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters

Biological Process

GO:0002227	innate immune response in mucosa
GO:0006401	RNA catabolic process
GO:0019731	antibacterial humoral response
GO:0045087	innate immune response
GO:0050830	defense response to Gram-positive bacterium
GO:0090501	RNA phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic