InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC1A2

Summary

InnateDB Protein

IDBP-238924.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC1A2

Protein Name

solute carrier family 1 (glial high affinity glutamate transporter), member 2

Synonyms

EAAT2; GLT-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000379099

InnateDB Gene

IDBG-39801 (SLC1A2)

Protein Structure

UniProt Annotation

Function

Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	6 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005313	L-glutamate transmembrane transporter activity
GO:0005515	protein binding
GO:0017153	sodium:dicarboxylate symporter activity

Biological Process

GO:0006811	ion transport
GO:0006835	dicarboxylic acid transport
GO:0007268	synaptic transmission
GO:0051938	L-glutamate import
GO:0055085	transmembrane transport
GO:0070779	D-aspartate import