InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AREG

Summary

InnateDB Protein

IDBP-238932.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AREG

Protein Name

amphiregulin

Synonyms

AR; AREGB; CRDGF; SDGF;

Species

Homo sapiens

Ensembl Protein

ENSP00000379097

InnateDB Gene

IDBG-24392 (AREG)

Protein Structure

UniProt Annotation

Function

Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

Subcellular Localization

Membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0014009	glial cell proliferation
GO:0014070	response to organic cyclic compound
GO:0031175	neuron projection development
GO:0032355	response to estradiol
GO:0042327	positive regulation of phosphorylation
GO:0042542	response to hydrogen peroxide
GO:0043434	response to peptide hormone
GO:0045668	negative regulation of osteoblast differentiation
GO:0045740	positive regulation of DNA replication
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP
GO:0060598	dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
GO:0060744	mammary gland branching involved in thelarche
GO:0060749	mammary gland alveolus development
GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation

Cellular Component

GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0016021	integral component of membrane