Version 5.4
Homo sapiens Protein: BTC
Summary
InnateDB Protein IDBP-238938.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BTC
Protein Name betacellulin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000379092
InnateDB Gene IDBG-24477 (BTC)
Protein Structure
UniProt Annotation
Function Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. {ECO:0000269PubMed:8570211}.
Subcellular Localization Betacellulin: Secreted, extracellular space.Probetacellulin: Cell membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine. {ECO:0000269PubMed:8919026}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0035810 positive regulation of urine volume
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response
GO:0045597 positive regulation of cell differentiation
GO:0045840 positive regulation of mitosis
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048146 positive regulation of fibroblast proliferation
GO:0051781 positive regulation of cell division
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000742 Epidermal growth factor-like domain
PFAM PF00008
PRINTS
PIRSF
SMART SM00181
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P35070
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 685
UniGene Hs.710156
RefSeq NP_001720
HUGO HGNC:1121
OMIM 600345
CCDS CCDS3566
HPRD 02643
IMGT
EMBL BC011618 S55606
GenPept AAB25452 AAH11618

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca