InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BTC

Summary

InnateDB Gene

IDBG-24477.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BTC

Gene Name

betacellulin

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000174808

Encoded Proteins

IDBP-238938

betacellulin

IDBP-473970

betacellulin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:74744759-74794686

Strand

Reverse strand

Band

q13.3

Transcripts

ENST00000395743	ENSP00000379092
ENST00000512743	ENSP00000421747

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0035810	positive regulation of urine volume
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response
GO:0045597	positive regulation of cell differentiation
GO:0045840	positive regulation of mitosis
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048146	positive regulation of fibroblast proliferation
GO:0051781	positive regulation of cell division