Version 5.4
Homo sapiens Protein: ADM2
Summary
InnateDB Protein IDBP-238954.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADM2
Protein Name adrenomedullin 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000379086
InnateDB Gene IDBG-13523 (ADM2)
Protein Structure
UniProt Annotation
Function IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway. {ECO:0000269PubMed:14615490}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed in the esophagus, stomach, jejunum, ileum, ileocecum, ascending colon, transverse colon, descending colon and rectum. Expressed in myocardial cells of the heart, renal tubular cells, hypothalamus, and pituitary. {ECO:0000269PubMed:14615490, ECO:0000269PubMed:16359754}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0032403 protein complex binding
Biological Process
GO:0001525 angiogenesis
GO:0006468 protein phosphorylation
GO:0010628 positive regulation of gene expression
GO:0045766 positive regulation of angiogenesis
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR021116 Procalcitonin/adrenomedullin
PFAM PF00214
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z4H4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 79924
UniGene Hs.743540
RefSeq
HUGO HGNC:28898
OMIM 608682
CCDS CCDS33682
HPRD 10563
IMGT
EMBL AB121034 AB236970 AF529213 AL096767
GenPept AAQ09100 BAD07411 BAE46395 CAO03464

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca