InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GABARAP

Summary

InnateDB Protein

IDBP-23902.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GABARAP

Protein Name

GABA(A) receptor-associated protein

Synonyms

ATG8A; GABARAP-a; MM46;

Species

Homo sapiens

Ensembl Protein

ENSP00000306866

InnateDB Gene

IDBG-23900 (GABARAP)

Protein Structure

UniProt Annotation

Function

Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. {ECO:0000269PubMed:15977068}.

Subcellular Localization

Endomembrane system {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000269PubMed:12507496, ECO:0000269PubMed:15169837, ECO:0000269PubMed:17580304, ECO:0000269PubMed:19056683}. Note=Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:11146101, ECO:0000269PubMed:9892355}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	67 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0048487	beta-tubulin binding
GO:0050811	GABA receptor binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0000226	microtubule cytoskeleton organization
GO:0006605	protein targeting
GO:0006914	autophagy
GO:0007268	synaptic transmission
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0015031	protein transport

Cellular Component

GO:0000139	Golgi membrane
GO:0000421	autophagic vacuole membrane
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005776	autophagic vacuole
GO:0005790	smooth endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0005886	plasma membrane
GO:0005930	axoneme
GO:0015629	actin cytoskeleton
GO:0031410	cytoplasmic vesicle
GO:0044297	cell body
GO:0048471	perinuclear region of cytoplasm