InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PURB

Summary

InnateDB Protein

IDBP-239023.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PURB

Protein Name

purine-rich element binding protein B

Synonyms

PURBETA;

Species

Homo sapiens

Ensembl Protein

ENSP00000379051

InnateDB Gene

IDBG-15418 (PURB)

Protein Structure

UniProt Annotation

Function

Has capacity to bind repeated elements in single- stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine- rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:1448097}.

Disease Associations

Tissue Specificity

Expressed in myocardium of heart failure patients. {ECO:0000269PubMed:12933792}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0044822	poly(A) RNA binding
GO:0046332	SMAD binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0045637	regulation of myeloid cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated