Version 5.4
Homo sapiens Gene: PURB
Summary
InnateDB Gene IDBG-15418.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PURB
Gene Name purine-rich element binding protein B
Synonyms PURBETA
Species Homo sapiens
Ensembl Gene ENSG00000146676
Encoded Proteins
IDBP-239023
purine-rich element binding protein B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:44876293-44885361
Strand Reverse strand
Band p13
Transcripts
ENST00000395699 ENSP00000379051
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0044822 poly(A) RNA binding
GO:0046332 SMAD binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045637 regulation of myeloid cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005662 DNA replication factor A complex
Orthologs
Species
Bos taurus
Mus musculus
Gene ID
Gene Order
ENSBTAG00000046625
Not yet available
ENSMUSG00000094483
View Gene Order
Cross-References
SwissProt Q96QR8
TrEMBL
UniProt Splice Variant
Entrez Gene 5814
UniGene Hs.710064 Hs.743235
RefSeq NM_033224
HUGO HGNC:9702
OMIM 608887
CCDS CCDS5499
HPRD
IMGT
EMBL AC004854 AY039216 BC101735 BC101737 CH236960 CH471128
GenPept AAI01736 AAI01738 AAK72462 AAS00366 EAL23749 EAW61073
RNA Seq Atlas 5814

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca