InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNTB1

Summary

InnateDB Protein

IDBP-239232.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNTB1

Protein Name

syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)

Synonyms

59-DAP; A1B; BSYN2; DAPA1B; SNT2; SNT2B1; TIP-43;

Species

Homo sapiens

Ensembl Protein

ENSP00000378965

InnateDB Gene

IDBG-34319 (SNTB1)

Protein Structure

UniProt Annotation

Function

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.

Subcellular Localization

Cell membrane, sarcolemma {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:8183929}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0030165	PDZ domain binding

Biological Process

GO:0006936

muscle contraction

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0016010	dystrophin-associated glycoprotein complex
GO:0030054	cell junction
GO:0042383	sarcolemma
GO:0043234	protein complex
GO:0045202	synapse