Version 5.4
Homo sapiens Gene: SNTB1
Summary
InnateDB Gene IDBG-34319.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNTB1
Gene Name syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
Synonyms 59-DAP; A1B; BSYN2; DAPA1B; SNT2; SNT2B1; TIP-43
Species Homo sapiens
Ensembl Gene ENSG00000172164
Encoded Proteins
IDBP-239232
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
IDBP-480013
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
IDBP-482123
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:120535745-120813273
Strand Reverse strand
Band q24.12
Transcripts
ENST00000395601 ENSP00000378965
ENST00000517992 ENSP00000431124
ENST00000519177
ENST00000519298
ENST00000520717 ENSP00000429292
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0030165 PDZ domain binding
Biological Process
GO:0006936 muscle contraction
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0016010 dystrophin-associated glycoprotein complex
GO:0030054 cell junction
GO:0042383 sarcolemma
GO:0043234 protein complex
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000060429
View Gene Order
ENSBTAG00000044126
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.46701 Hs.670611 Hs.670666 Hs.714020
RefSeq NM_021021 XM_005251031
HUGO
OMIM
CCDS CCDS6334
HPRD 02490
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca