InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZHX1

Summary

InnateDB Protein

IDBP-239293.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZHX1

Protein Name

zinc fingers and homeoboxes 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000378938

InnateDB Gene

IDBG-34656 (ZHX1)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional repressor. Increases DNMT3B- mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co- repressor proteins. {ECO:0000269PubMed:12237128}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:12237128, ECO:0000269PubMed:17056598}. Note=Colocalized in the nucleus with DNMT3B.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Expressed in podocytes. {ECO:0000269PubMed:10441475, ECO:0000269PubMed:17056598}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.

Experimentally validated
Total	73 [view]
Protein-Protein	72 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0030154	cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated